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It promotes inflammation via NF-B pathway activation (82) and by activating the NLRP3 inflammasome in endothelial cells and arterial walls in mice, involving mitochondrial ROS, TXNIP, and lysosomal instability (101, 134)
10.1182/blood-2010-12-324939 Blood 43 LeytonM
36,37 Chemical synthesis is widely regarded as the the most advanced technology for the production of therapeutic peptides particularly following the advent of solid-phase peptide synthesis (SPPS)
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